There is no one cause of depression. We view depression as “multi-determined” that is, a number of different factors can cause it. These factors can be biochemical, interpersonal, behavioral, or cognitive. Depression may be caused in some people by factors in one of these areas, but it is just as likely to be caused by a combination of factors from all these areas. Biochemical factors can include your family’s genetic predisposition and your current brain chemistry. Conflicts and losses in interpersonal relationships can be factors in causing depression, as can behavioral factors, such as increases in stress and decreases in positive, enjoyable experiences. Cognitive factors include various distorted and maladaptive ways of thinking. let us look at the behavioral and cognitive factors in a little more detail.